Polypoid growth and K-ras codon 12 mutation in coiorectal cancer
نویسندگان
چکیده
منابع مشابه
codon 12 k-ras mutation detection in iranian patients with colorectal cancer using pcr-rflp method
colorectal cancer (crc) is one of the most common cancers worldwide. understanding of the tumor behavior, in a much closer look, at the molecular level, results in a more effective treatment and accurate prognosis of the disease. from among various genes altered in colorectal cancer k-ras is assumed to be of diagnostic and prognostic significance. k-ras mutations are believed to be a critical e...
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A significant association between N-ras oncogene activating point mutations and testicular cancer has recently been reported. We have studied DNA samples from the blood and fresh tumor tissues of 17 Norwegian testicular cancer patients (11 seminomas/6 nonseminomas). Point mutations in K-ras-2 and N-ras exons 1 and 2 were studied by denaturing gradient gel electrophoresis (DGGE) and by oligonucl...
متن کاملSignificance of the K-ras Gene Codon 12 Point Mutation in Stomach Cancer in Southern India
The frequency and clinicopathologic significance of the K-ras gene point mutation in stomach cancer remain to be defined. We investigated the frequency of K-ras codon 12 point mutations in stomach cancer using a polymerase chain reaction (PCR)-based method in 94 samples and 100 age and sex matched controls. The overall frequency of K-ras codon 12 point mutations in stomach cancer was 3.19% (3/9...
متن کاملPeutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations.
BACKGROUND Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant, polyposis syndrome, associated with an increased risk of gastrointestinal and extragastrointestinal malignancy. Occasionally dysplasia occurs in PJS polyps. AIMS In colorectal carcinomas, mutations in codon 12 of the K-ras oncogene are common and are found at similar frequency in precursor adenomas. Therefore, K-ras codon ...
متن کاملInfrequent K-ras codon 12 mutation in serrated adenomas of human colorectum.
BACKGROUND Serrated adenoma is a new morphological subtype of colorectal adenoma. The lesion provides a distinct morphological route to carcinoma, but the underlying genetic changes have not yet been investigated. AIMS To determine the frequency of K-ras mutation in serrated adenoma. METHODS The frequency of K-ras codon 12 point mutation in 20 serrated adenomas, five atypical hyperplastic p...
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ژورنال
عنوان ژورنال: Cancer
سال: 1995
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19950215)75:4<953::aid-cncr2820750409>3.0.co;2-r